I ran across this today. It took me a long time to find the right solution, so I thought I would post it here.
The error message I was getting was:
Failed to invoke operation load on MBean oracle.as.management. mbeans.register:type=component,name=ohs1,instance=asinst_1, Location=AdminServer Load failed with IOException
The logs further showed the following:
OHS-2079 nzos handshake error, nzos_Handshake returned 28860(server obscured.server.com:9999, client 111.127.66.159) OHS-2171 NZ Library Error: SSL fatal alert
The fix I found towards the end of a thread at https://forums.oracle.com/forums/thread.jspa?threadID=1054032:
ORACLE_HOME\opmn\bin\upgradenonj2eeapp.bat -oracleInstance Instance_Home_Location -adminHost WebLogic_Server_Host_Name -adminPort administration_server_port_number -adminUsername administration_server_user
Change it to .sh for Linux/Unix. I found I only had to run this on the first server in the farm rather than all of them as one might expect. Your mileage may vary.